Scientists were concerned about the project's environmental impact, as Lake Nicaragua is Central America's key freshwater reservoir  while the project's viability was questioned by shipping experts and engineers. Construction of a canal using the San Juan River as an access route to Lake Nicaragua was first proposed in the early colonial era. The United States abandoned plans to construct a waterway in Nicaragua in the early 20th century after it purchased the French interests in the Panama Canal. In , media reports suggested the project would be delayed and possibly cancelled because Wang's personal wealth declined greatly as a result of the —16 Chinese stock market crash. By May , no concrete action had been reportedly taken constructing the canal and further doubts were expressed about its financing.
Marcia Cross spoke out about diagnosis to 'put a dent in the stigma around anal cancer'
Irish Trails - Grand Canal Way
It closed to commercial traffic in , but in recent decades the canal has been restored for amenity use, and is well-frequented by pleasure craft of all kinds. The route is an informal linear park punctuated by the locks that characterise canal technology, carefully restored surviving lock-keepers cottages, and the towns and villages whose existence is owed to the trade and commerce the canal brought in the 18th and 19th centuries. Much of the landscape through which the route passes has been untouched by modern agriculture and remains a linear oasis for the flora and fauna that was originally common throughout our countryside. The many towns and villages along the way provide walkers with accommodation possibilities along the route, and as public transport options are good, these places can act as starting and finishing points for those who want to sample only sections of the route. There may be issues with waymarking at some points along the trail.
Grand Canal Way
Anal furunculosis is a chronic, progressive inflammation of the area surrounding the anus. This painful disease causes one or more fistulas in the anal area which can become very deep. Anal furunculosis is common in especially German Shepherds, even though it is also seen in other breeds. The disease is believed to be immune-mediated and is treated with immunosuppressive drugs. Anal furunculosis research has been done in Finland and in England at the same time.
Matthew M. The understanding and treatment of anal cancer has evolved over the past several decades. This has become particularly important as the incidence of anal cancer has increased. At an epidemiologic level, the human papilloma virus HPV vaccine has offered the possibility of primary prevention of cancer development. For those diagnosed with anal cancer, multimodal therapy with chemotherapy and radiation is the cornerstone of anal cancer treatment, with surgery generally reserved for those who have progression of disease despite chemoradiation.